targets and emerging therapies for schizophrenia

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Targets And Emerging Therapies For Schizophrenia

Author : Jeffrey S. Albert
ISBN : 9781118309407
Genre : Medical
File Size : 86. 95 MB
Format : PDF
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New and emerging directions in pharmaceutical research to better treat schizophrenia Although the dopamine hypothesis has been the cornerstone of schizophrenia therapeutics, it is clear that dopamine-based approaches do not treat all aspects of the disease. Moreover, many schizophrenia patients fail to respond to current antipsychotics. Integrating chemistry, biology, and pharmacology, this book explores emerging directions in pharmaceutical research for drug targeting and discovery in order to find more effective treatments for schizophrenia, one of the most serious and widespread psychiatric diseases. Targets and Emerging Therapies for Schizophrenia presents the basics of schizophrenia, drug targets for the disease, and potential new drugs and therapeutics. It begins with a discussion of prevalence and etiology. Then, it describes therapies such as dopamine agonists and phosphodiesterase (PDE) inhibitors as well as growing research aimed at addressing untreated symptoms. Next, the authors discuss receptor modulators, inhibitors, and targeting strategies for drug discovery. Both the neurobiological and chemical aspects of all major pharmacological targets are examined. With contributions from an international team of pioneering pharmaceutical researchers, this book compiles the current knowledge in the field, setting the stage for new breakthroughs in the treatment of schizophrenia. Targets and Emerging Therapies for Schizophrenia: Provides a comprehensive resource for neuro-drug discovery and the development of molecular targets for schizophrenia treatment Draws from chemistry, biology, and pharmacology for more effective drug targeting and discovery Explores a wide range of receptors and molecular targets, including dopamine, PDEs, and neuropeptides With Targets and Emerging Therapies for Schizophrenia as their guide, drug discovery and development scientists have the information they need to advance their own research so that new, more effective treatments for schizophrenia will soon be a reality.

Novel Antischizophrenia Treatments

Author : Mark A. Geyer
ISBN : 9783642257575
Genre : Medical
File Size : 71. 76 MB
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This volume will try to put current therapy - achievements, shortcomings, remaining medical needs - and emerging new targets into the context of increasing knowledge regarding the genetic and neurodevelopmental contributions to the pathophysiology of schizophrenia. Some of the chapters will also deal with respective experimental and clinical methodology, biomarkers, and translational aspects of drug development. The volume will concentrate on reviewing the ongoing research attempting to identify novel treatments for the cognitive deficits and negative symptoms of schizophrenia, which are not treated adequately by current antipsychotic medications.

Gpcr Molecular Pharmacology And Drug Targeting

Author : Annette Gilchrist
ISBN : 1118035178
Genre : Medical
File Size : 30. 20 MB
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G protein-coupled receptors (GPCRs) are a large protein family of transmembrane receptors vital in dictating cellular responses. GPCRs are involved in many diseases, but are also the target of around half of all modern medicinal drugs. Shifting Paradigms in G Protein Coupled Receptors takes a look at the way GPCRs are examined today, how they react, how their mutations lead to disease, and the many ways in which they can be screened for compounds that modulate them. Chemists, pharmacologists, and biologists will find essential information in this comprehensive reference.

Cognitive Remediation Therapy For Schizophrenia

Author : Professor Til Wykes
ISBN : 9781135444099
Genre : Psychology
File Size : 63. 41 MB
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Could CRT provide the first structured method of alleviating cognitive deficits associated with schizophrenia? Cognitive Remediation Therapy for Schizophrenia describes the background and development of this new psychological therapy and demonstrates how it provides the first structured help to overcome the thinking problems associated with schizophrenia. In three sections, the book covers the theoretical and empirical underpinning of cognitive remediation therapy and explores its application. Part I, 'The Development of Therapy', provides the historical context and theoretical background to the therapy and emphasizes the value of rehabilitating cognitive deficits. In Part II, 'Improving Cognitive Processes', the process and effects of changing cognition are examined. Finally, in Part III, 'The Process of Therapy', the authors provide a clinical guide to the delivery of cognitive remediation therapy and use case examples to support its efficacy. This book is the first to describe an individual cognitive remediation therapy programme based on a clear model of the relationship between thinking and behaviour. It will be of both academic and clinical value to all those health professionals and clinical academics who want not only to understand the relationships between thought and action but also to intervene to improve therapy.

Comprehensive Care Of Schizophrenia

Author : Jeffrey A. Lieberman
ISBN : 9780195388015
Genre : Medical
File Size : 89. 68 MB
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The second edition of this popular volume has been thoroughly updated, offering new information on the advances in research and management since the publication of the first edition a decade ago.

Therapy In Sleep Medicine

Author : Teri J. Barkoukis
ISBN : 9781455723300
Genre : Medical
File Size : 43. 22 MB
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Therapy in Sleep Medicine, by Drs. Teri J. Barkoukis, Jean K. Matheson, Richard Ferber, and Karl Doghrami, provides the clinically focused coverage you need for rapid diagnosis and effective treatment of sleep disorders. A multidisciplinary team of leading authorities presents the latest on sleep breathing disorders (including obstructive sleep apnea), neuropharmacology, parasomnias, neurologic disorders affecting sleep, sleep therapy for women, sleep therapy in geriatric patients, controversies, and future trends in therapy in a highly illustrated, easy-to-follow format. Diagnose and treat patients effectively with complete coverage of the full range of sleep disorders. Find diagnostic and treatment information quickly and easily thanks to a highly illustrated, easy-to-read format that highlights key details. Stay current on discussions of hot topics, including sleep breathing disorders (including obstructive sleep apnea), neuropharmacology, parasomnias, neurologic disorders affecting sleep, sleep therapy for women, sleep therapy in geriatric patients, controversies, and future trends in therapy. Tap into the expertise of a multidisciplinary team of leading authorities for well-rounded, trusted guidance.

Peptide Chemistry And Drug Design

Author : Ben M. Dunn
ISBN : 9781118996416
Genre : Medical
File Size : 68. 65 MB
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This book focuses on peptides as drugs, a growing area of pharmaceutical research and development. It helps readers solve problems of discovering, developing, producing, and delivering peptide-based drugs. • Identifies promising new areas in peptide drug discovery • Includes chapters on discovery from natural sources, metabolic modification, and drug delivery • Overviews separation methods and techniques for analysis, bond formation, and purification • Offers readers both a professional reference and a text or resource for graduate-level students

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