in silico methods for predicting drug toxicity methods in molecular biology book 1425

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In Silico Methods For Predicting Drug Toxicity

Author : Emilio Benfenati
ISBN : 1493936093
Genre : Biomedicine
File Size : 71. 67 MB
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This detailed volume explores in silico methods for pharmaceutical toxicity by combining the theoretical advanced research with the practical application of the tools. Beginning with a section covering sophisticated models addressing the binding to receptors, pharmacokinetics and adsorption, metabolism, distribution, and excretion, the book continues with chapters delving into models for specific toxicological and ecotoxicological endpoints, as well as broad views of the main initiatives and new perspectives which will very likely improve our way of modelling pharmaceuticals. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detailed implementation advice that is key for achieving successful research results. Authoritative and practical, In Silico Methods for Predicting Drug Toxicity offers the advantage of incorporating data and knowledge from different fields, such as chemistry, biology, -omics, and pharmacology, to achieve goals in this vital area of research.

Molecular Modeling And Simulation

Author : Tamar Schlick
ISBN : 9780387224640
Genre : Science
File Size : 88. 36 MB
Format : PDF
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Very broad overview of the field intended for an interdisciplinary audience; Lively discussion of current challenges written in a colloquial style; Author is a rising star in this discipline; Suitably accessible for beginners and suitably rigorous for experts; Features extensive four-color illustrations; Appendices featuring homework assignments and reading lists complement the material in the main text

Real World Drug Discovery

Author : Robert M. Rydzewski
ISBN : 0080914888
Genre : Medical
File Size : 69. 51 MB
Format : PDF, Kindle
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Drug discovery increasingly requires a common understanding by researchers of the many and diverse factors that go into the making of new medicines. The scientist entering the field will immediately face important issues for which his education may not have prepared him: project teams, patent law, consultants, target product profiles, industry trends, Gantt charts, target validation, pharmacokinetics, proteomics, phenotype assays, biomarkers, and many other unfamiliar topics for which a basic understanding must somehow be obtained. Even the more experienced scientist can find it frustratingly difficult to get an overview of the many factors involved in modern drug discovery and often only after years of exploring does a whole and integrated picture emerge in the mind of the researcher. Real World Drug Discovery: A Chemist’s Guide to Biotech and Pharmaceutical Research presents this kind of map of the landscape of drug discovery. In a single, readable volume it outlines processes and explains essential concepts and terms for the recent science graduate wondering what to expect in pharma or biotech, the medicinal chemist seeking a broader and more timely understanding of the industry, or the contractor or collaborator whose understanding of the commercial drug discovery process could increase the value of his contribution to it. Interviews with well-known experts in many of the fields involved, giving insightful comments from authorities on many of the sub-disciplines important to cutting edge drug discovery. Helpful suggestions gleaned from years of experience in biotech and pharma, which represents a repository drug discovery "lore" not previously available in any book. "Periodic Table of Drugs" listing current top-selling drugs arranged by target and laid out so that structural similarities and differences are plain and clear. Extensive use of diagrams to illustrate concepts like biotech startup models, preteomic profiling for target identification, Gantt charts for project planning, etc.

Handbook Of Drug Nutrient Interactions

Author : Joseph I. Boullata
ISBN : 160327362X
Genre : Science
File Size : 78. 65 MB
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Handbook of Drug-Nutrient Interactions, Second Edition is an essential new work that provides a scientific look behind many drug-nutrient interactions, examines their relevance, offers recommendations, and suggests research questions to be explored. In the five years since publication of the first edition of the Handbook of Drug-Nutrient Interactions new perspectives have emerged and new data have been generated on the subject matter. Providing both the scientific basis and clinical relevance with appropriate recommendations for many interactions, the topic of drug-nutrient interactions is significant for clinicians and researchers alike. For clinicians in particular, the book offers a guide for understanding, identifying or predicting, and ultimately preventing or managing drug-nutrient interactions to optimize patient care. Divided into six sections all chapters have been revised or are new to this edition. Chapters balance the most technical information with practical discussions and include outlines that reflect the content; discussion questions that can guide the reader to the critical areas covered in each chapter, complete definitions of terms with the abbreviation fully defined and consistent use of terms between chapters. The editors have performed an outstanding service to clinical pharmacology and pharmaco-nutrition by bringing together a multi-disciplinary group of authors. Handbook of Drug-Nutrient Interactions, Second Edition is a comprehensive up-to-date text for the total management of patients on drug and/or nutrition therapy but also an insight into the recent developments in drug-nutrition interactions which will act as a reliable reference for clinicians and students for many years to come.

Oecd Guidelines For The Testing Of Chemicals Oecd Series On Testing And Assessment Detailed Review Document On Classification In Oecd Member Countries Of Substances And Mixtures Which Cause Respiratory Tract Irritation And Corrosion

Author : OECD
ISBN : 9789264079090
Genre :
File Size : 23. 34 MB
Format : PDF
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This detailed review documents examines member country classification of substances and mixtures which cause respiratorytract irritation and corrosion.

Drug Design

Author : Kenneth M. Merz, Jr
ISBN : 9780521887236
Genre : Medical
File Size : 63. 50 MB
Format : PDF, Docs
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This book provides a complete snapshot of various experimental approaches to structure-based and ligand-based drug design and is illustrated with more than 200 images.

Molecular Genetics Of Mycobacteria

Author : Graham F. Hatfull
ISBN : UOM:39015053154103
Genre : Science
File Size : 54. 68 MB
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A new specialist research–level monograph, discussing mycobacterial genetics in the context of the whole genome. An essential reference that describes the recent advances in the field and a useful guide for the new generation of researchers working in the post–genomic area.

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