flavonoid pharmacokinetics methods of analysis preclinical and clinical pharmacokinetics safety and toxicology

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Flavonoid Pharmacokinetics

Author : Neal M. Davies
ISBN : 9781118354407
Genre : Science
File Size : 62. 34 MB
Format : PDF
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SETS FORTH A FRAMEWORK FOR THE ANALYSIS AND STUDY OF FLAVONOIDS More and more dietary supplements contain flavonoids. These products are typically viewed as food rather than drug products by regulatory agencies and therefore not subjected to rigorous clinical trials before they are marketed to the general public. As a result, the use of flavonoid-containing supplements presents a potential public health risk. From discovery to therapeutic application, this book is a comprehensive guide to both achiral and chiral flavonoids, enabling researchers to perform essential preclinical and clinical pharmacokinetics studies in order to ensure the efficacy of flavonoids marketed for therapeutic use. Moreover, the book examines the safety and toxicology of flavonoids as well as flavonoid-drug interactions. With contributions from a multidisciplinary team of leading researchers, Flavonoids Pharmacokinetics reviews and synthesizes the most recent research findings and results from preclinical and clinical studies. The book begins with a comprehensive overview of polyphenols and flavonoids. Next, the book covers: Methods of analysis of achiral flavonoids Preclinical pharmacokinetic of flavonoids Toxicology and safety of flavonoids Methods of analysis for chiral flavonoids Clinical pharmacokinetics of flavonoids Flavonoids and drug interactions Throughout the book, the authors provide examples that demonstrate the use of pharmacokinetics concepts during the preclinical and clinical drug development process. Flavonoid Pharmacokinetics is written for pharmaceutical, food, and nutritional scientists and students, offering the tools they need to thoroughly analyze and test flavonoids and flavonoid-containing supplements to ensure their safety and efficacy.

Capillary Electrophoresis And Microchip Capillary Electrophoresis

Author : Carlos D. García
ISBN : 9781118529997
Genre : Science
File Size : 20. 58 MB
Format : PDF, Docs
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Explores the benefits and limitations of the latest capillary electrophoresis techniques Capillary electrophoresis and microchip capillary electrophoresis are powerful analytical tools that are particularly suited for separating and analyzing biomolecules. In comparison with traditional analytical techniques, capillary electrophoresis and microchip capillary electrophoresis offer the benefits of speed, small sample and solvent consumption, low cost, and the possibility of miniaturization. With contributions from a team of leading analytical scientists, Capillary Electrophoresis and Microchip Capillary Electrophoresis explains how researchers can take full advantage of all the latest techniques, emphasizing applications in which capillary electrophoresis has proven superiority over other analytical approaches. The authors not only explore the benefits of each technique, but also the limitations, enabling readers to choose the most appropriate technique to analyze a particular sample. The book's twenty-one chapters explore fundamental aspects of electrophoretically driven separations, instrumentation, sampling techniques, separation modes, detection systems, optimization strategies for method development, and applications. Specific topics include: Critical evaluation of the use of surfactants in capillary electrophoresis Sampling and quantitative analysis in capillary electrophoresis Capillary electrophoresis with electrochemical detection Overcoming challenges in using microchip electrophoresis for extended monitoring applications Capillary electrophoresis of intact unfractionated heparin and related impurities Microchip capillary electrophoresis for in situ planetary exploration Each chapter begins with an introduction and ends with conclusions as well as references to the primary literature. Novices to the field will find this book an easy-to-follow introduction to core capillary electrophoresis techniques and methods. More experienced investigators can turn to the book for troubleshooting tips and expert advice to guide them through the most advanced applications.

Adme Enabling Technologies In Drug Design And Development

Author : Donglu Zhang
ISBN : 9781118180747
Genre : Science
File Size : 90. 24 MB
Format : PDF, Kindle
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Mass Spectrometry Handbook

Author : Mike S. Lee
ISBN : 9781118180723
Genre : Science
File Size : 49. 61 MB
Format : PDF, ePub
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Due to its enormous sensitivity and ease of use, mass spectrometry has grown into the analytical tool of choice in most industries and areas of research. This unique reference provides an extensive library of methods used in mass spectrometry, covering applications of mass spectrometry in fields as diverse as drug discovery, environmental science, forensic science, clinical analysis, polymers, oil composition, doping, cellular research, semiconductor, ceramics, metals and alloys, and homeland security. The book provides the reader with a protocol for the technique described (including sampling methods) and explains why to use a particular method and not others. Essential for MS specialists working in industrial, environmental, and clinical fields.

Fundamentals Of Heterocyclic Chemistry

Author : Louis D. Quin
ISBN : 0470626534
Genre : Science
File Size : 46. 39 MB
Format : PDF, Kindle
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Heterocyclic chemistry is of prime importance as a sub-discipline of Organic Chemistry, as millions of heterocyclic compounds are known with more being synthesized regularly Introduces students to heterocyclic chemistry and synthesis with practical examples of applied methodology Emphasizes natural product and pharmaceutical applications Provides graduate students and researchers in the pharmaceutical and related sciences with a background in the field Includes problem sets with several chapters

Phytotherapies

Author : Iqbal Ramzan
ISBN : 9781119006114
Genre : Medical
File Size : 27. 20 MB
Format : PDF, ePub
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Covering fundamentals and new developments in phytotherapy, this book combines pharmaceutical sciences and chemistry with clinical issues. • Helps readers better understand phytotherapy and learn the fundamentals of and how to analyze phytotherapeutic agents • Discusses phytotherapy in modern medicine, chemoprevention of disease, and alternatives to western medicines for specific diseases • Chapters summarizes the uses and applications of phytomedicines, by type like Chinese, Greco-Arab, Indian, European, and Ayurvedic • Includes international regulatory perspectives and discusses emerging regulations for various established and emerging markets

Prescribing Scenarios At A Glance

Author : Emma Baker
ISBN : 9781118570876
Genre : Medical
File Size : 73. 8 MB
Format : PDF
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Prescribing Scenarios at a Glance is an innovative resource which allows medical students and junior doctors to practise prescribing skills safely for themselves. Supporting those who wish to develop their prescribing knowledge and clinical reasoning, this book features 50 acute and on call scenarios in a hospital setting. Users will be able to practise skills such as initiating a prescription, planning management, reviewing therapy, and identifying adverse drug reactions and interactions. Prescribing Scenarios at a Glance: • Contains case scenarios, mock drug charts and model answers with discussion • Features a workbook of prepared drug charts for each case that allow users to practise prescription writing • Includes detailed explanations and answers to all case scenarios, including examples of correctly completed charts • Includes access to refill drug charts for each scenario available on the companion website at www.ataglanceseries.com/prescribingscenarios, allowing users to rehearse each scenario as many times as they like An ideal companion for medical students, foundation doctors and non-medical prescribers as they develop their prescribing skills, this book will help to instil confidence, reduce errors, and encourage best practice. It will also be a valuable resource for candidates preparing for prescribing exams. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from iTunes, Google Play or the MedHand Store.

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