drug repositioning bringing new life to shelved assets and existing drugs

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Drug Repositioning

Author : Michael J. Barratt
ISBN : 9781118274392
Genre : Medical
File Size : 64. 56 MB
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The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opportunities that drug repositioning offers. Readers will learn how to perform the latest experimental and computational methods that support drug repositioning, and detailed case studies throughout the book demonstrate how these methods fit within the context of a comprehensive drug repositioning strategy. Drug Repositioning is divided into three parts: Part 1, Drug Repositioning: Business Case, Strategies, and Operational Considerations, examines the medical and commercial drivers underpinning the quest to reposition existing drugs, guiding readers through the key strategic, technical, operational, and regulatory decisions needed for successful drug repositioning programs. Part 2, Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs, sets forth computational-based strategies, tools, and databases that have been designed for repositioning studies, screening approaches, including combinations of existing drugs, and a look at the development of chemically modified analogs of approved agents. Part 3, Academic and Non-Profit Initiatives & the Role of Alliances in the Drug Repositioning Industry, explores current investigations for repositioning drugs to treat rare and neglected diseases, which are frequently overlooked by for-profit pharmaceutical companies due to their lack of commercial return. The book's appendix provides valuable resources for drug repositioning researchers, including information on drug repositioning and reformulation companies, databases, government resources and organizations, regulatory agencies, and drug repositioning initiatives from academia and non-profits. With this book as their guide, students and pharmaceutical researchers can learn how to use drug repositioning techniques to extend the lifespan and applications of existing drugs as well as maximize the return on investment in drug research and development.

Drug Repositioning

Author : Michael J. Barratt
ISBN : 9781118274378
Genre : Medical
File Size : 33. 28 MB
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The Chemistry And Biology Of Volatiles

Author : Andreas Herrmann
ISBN : 9781119956983
Genre : Science
File Size : 58. 59 MB
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"Coming to a conclusion, this wonderful, informative and very interesting book presents an excellent overview of small volatile organic compounds and their role in our life and environment. Really fascinating is the entirety of scientific disciplines which were addressed by this book." –Flavour and Fragrance Journal, 2011 "… this book deserves to be a well-used reference in the library of any laboratory specialising in VOC". –Chemistry World, 2011 Volatile compounds are molecules with a relatively low molecular weight allowing for an efficient evaporation into the air. They are found in many areas of our everyday-life: they are responsible for the communication between species such as plants, insects or mammals; they serve as flavours or fragrances in many food products or perfumed consumer articles; and they play an important role in atmospheric chemistry. This book takes an interdisciplinary approach to volatile molecules. Review-style introductions to the main topics in volatile chemistry and biology are provided by international experts, building into a broad overview of this fascinating field. Topics covered include: The structural variety of volatile compounds Biogeneration of volatiles Synthesis of natural and non-natural volatiles Analysis of volatiles Volatile compounds as semiochemicals in plant-plant or plant-insect interactions Volatiles in pest control Pheromones and the influence of volatiles on mammals Olfaction and human perception Volatiles as fragrances The generation of flavours and food aroma compounds Stabilisation and controlled release of volatiles The impact of volatiles on the environment and the atmosphere

Nonclinical Safety Assessment

Author : William J. Brock
ISBN : 9781118516980
Genre : Medical
File Size : 55. 40 MB
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Bringing a new drug to market is a costly time-consuming process. Increased regional and international regulation over the last twenty years, while necessary, has only served to amplify these costs. In response to this escalation, developmental strategies have shifted towards a more global approach. In order to create the most cost-effective and safe processes, it is critical for those bringing drugs to market to understand both the globally accepted regulations and the local variations. Nonclinical Safety Assessment: A Guide to International Pharmaceutical Regulations provides a practical description of nonclinical drug development regulations and requirements in the major market regions. It includes: ICH – the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use National regulations, including US FDA, Canada, Mercosur and Brazil, South Africa, China, Japan, India and Australia Repeated dose toxicity studies Carcinogenicity; Genotoxicity; Developmental and reproductive toxicology; Immunotoxicology Biotechnology-derived pharmaceuticals Vaccine development Phototoxicity and photocarcinogenicity Degradants, impurities, excipients and metabolites Primarily intended for those professionals actively involved in the nonclinical and clinical development of a pharmaceutical product, including toxicologists, pharmacologists, clinicians and project managers, this book provides a roadmap for successful new drug approval and marketing.

A Practical Guide To Drug Development In Academia

Author : Daria Mochly-Rosen
ISBN : 9783319022017
Genre : Medical
File Size : 82. 56 MB
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"A lot of hard-won knowledge is laid out here in a brief but informative way. Every topic is well referenced, with citations from both the primary literature and relevant resources from the internet." Review from Nature Chemical Biology Written by the founders of the SPARK program at Stanford University, this book is a practical guide designed for professors, students and clinicians at academic research institutions who are interested in learning more about the drug development process and how to help their discoveries become the novel drugs of the future. Often many potentially transformative basic science discoveries are not pursued because they are deemed ‘too early’ to attract industry interest. There are simple, relatively cost-effective things that academic researchers can do to advance their findings to the point that they can be tested in the clinic or attract more industry interest. Each chapter broadly discusses an important topic in drug development, from preclinical work in assay design through clinical trial design, regulatory issues and marketing assessments. After the practical overview provided here, the reader is encouraged to consult more detailed texts on specific topics of interest. "I would actually welcome it if this book’s intended audience were broadened even more. Younger scientists starting out in the drug industry would benefit from reading it and getting some early exposure to parts of the process that they’ll eventually have to understand. Journalists covering the industry (especially the small startup companies) will find this book a good reality check for many an over-hopeful press release. Even advanced investors who might want to know what really happens in the labs will find information here that might otherwise be difficult to track down in such a concentrated form."

Clinical Data Management

Author : Richard K. Rondel
ISBN : 0471983292
Genre : Medical
File Size : 58. 90 MB
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Extensively revised and updated, with the addition of new chapters and authors, this long-awaited second edition covers all aspects of clinical data management. Giving details of the efficient clinical data management procedures required to satisfy both corporate objectives and quality audits by regulatory authorities, this text is timely and an important contribution to the literature. The volume: * is written by well-known and experienced authors in this area * provides new approaches to major topics in clinical data management * contains new chapters on systems software validation, database design and performance measures. It will be invaluable to anyone in the field within the pharmaceutical industry, and to all biomedical professionals working in clinical research.

Proceedings Of The International Conference On Inter Disciplinary Research In Engineering And Technology 2015

Author : Kokula Krishna Hari Kunasekaran
ISBN : 9788192974255
Genre : Computers
File Size : 76. 96 MB
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Welcome to the International Conference on Inter Disciplinary Research in Engineering and Technology (ICIDRET) 2015 in DSIIDC, Government of NCT, New Delhi, India, Asia on 29 – 30 April, 2015. If this is your first time to New Delhi, you need to look on more objects which you could never forget in your lifetime. There is much to see and experience at The National Capital of Republic of India. The concept of Inter Disciplinary research was a topic of focus by various departments across the Engineering and Technology area. Flushing with major areas, this ICIDRET ’15 has addressed the E&T areas like Mechanical Engineering, Civil Engineering, Electrical Engineering, Bio-Technology, Bio-Engineering, Bio-Medical, Computer Science, Electronics & Communication Engineering, Management and Textile Engineering. This focus has brought a new insight on the learning methodologies and the terminology of accepting the cross definition of engineering and the research into it. We invite you to join us in this inspiring conversation. I am pretty sure that this conference would indulge the information from the various parts of the world and could coin as a global research gathering. With more and more researchers coming into ICIDRET, this event would be as an annual event. This conference is sure that, this edition and the future edition will serve as a wise platform for the people to come with better research methodologies integrating each and every social component globally. If there would have been a thought of not integrating the RJ45 and few pieces of metal / plastic along with a PCB, today we could haven’t used the telephones and mobile phones. With an ear-mark inspiration and constant support from the Global President Dr. S. Prithiv Rajan, ASDF International President Dr. P. Anbuoli, this publication stands in front of your eyes, without them this would haven’t been possible in a very shortest span. Finally, I thank my family, friends, students and colleagues for their constant encouragement and support for making this type of conference. -- Kokula Krishna Hari K Editor-in-Chief www.kokulakrishnaharik.in

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